MicroRNAs in NF- B signaling

colorectal cancer and nf-?b signaling pathway

colorectal cancer (crc) is the second leading cause of cancer death. progress has been made in the development of chemotherapy for advanced crc. targeted therapies against vegf or egfr are now commonly used. however, many cases show that tolerance develops to such treatments; therefore, new strategies are required to replace or complement current therapies. nuclear factor-?b (nf-?b) transcripti...

Signaling to NF - B

MicroRNAs Modulate the Dynamics of the NF-κB Signaling Pathway

BACKGROUND NF-κB, a major transcription factor involved in mammalian inflammatory signaling, is primarily involved in regulation of response to inflammatory cytokines and pathogens. Its levels are tightly regulated since uncontrolled inflammatory response can cause serious diseases. Mathematical models have been useful in revealing the underlying mechanisms, the dynamics, and other aspects of r...

LAT-derived microRNAs in HSV-1 target SMAD3 and SMAD4 in TGF-β/Smad signaling pathway

Background: During its latent infection, HSV-1 produces only a miRNA precursor called LAT, which encodes six distinct miRNAs. Recent studies have suggested that some of these miRNAs could target cellular mRNAs. One of the key cell signaling pathways that can be affected by HSV-1 is the TGF-β/Smad pathway. Herein, we investigated the potential role of the LAT as well as three LAT-derived miRNAs ...

TLR3-mediated NF- B signaling in human esophageal epithelial cells

Lim DM, Narasimhan S, Michaylira CZ, Wang ML. TLR3mediated NFB signaling in human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol 297: G1172–G1180, 2009. First published September 24, 2009; doi:10.1152/ajpgi.00065.2009.—Despite its position at the front line against ingested pathogens, very little is presently known about the role of the esophageal epithelium in host innate...